A Ret-HC (Hydroquinone/Tretinoin/Hydrocortisone Acetate)


A Ret-HC (Hydroquinone/Tretinoin/Hydrocortisone Acetate) is a triple combination skin lightening cream used to treat hyperpigmentation on the skin. Its mechanism of action is reducing the amount of pigments such as melanin. This helps to lighten unwanted areas of darkened skin, including melasma (due to sun damage), chloasma, freckles, age spots and senile lentigines. Hydroquinone is a compound widely used in cosmetics for its ability to decrease the skin color, leading to whitening. By affecting the synthesis of the pigment melanin, it can gradually bleach the skin, thereby treating unwanted dark spots.

Tretinoin (a type of vitamin A also known as retinoic acid) is frequently used in dermatology. It helps to increase the penetration of hydroquinone through the outer skin (stratum corneum), while also preventing the oxidation of hydroquinone, thereby enhancing its effects. In addition to this, it may also improve the rate at which the pigment is removed due to the fact that it increases the turnover rate of keratinocytes, while also helping to reduce the appearance of some fine wrinkles. Finally, hydrocortisone is added for its anti-inflammatory properties. It helps to lessen inflammation on the skin.

Dosage and Administration

A Ret-HC (Hydroquinone/Tretinoin/Hydrocortisone Acetate) cream is intended for application directly to the area of skin that is affected by hyperpigmentation. It is possible that your physician will instruct you to apply the cream once every day, at night. The duration of treatment may vary depending on your symptoms, and in all cases, the physician providing treatment will decide how long you need to continue treatment for. Regular assessment of your progress may be necessary, and your physician may schedule medical appointments in order to ensure that the cream is having its desired effects.

Side effects

Treatment of hyperpigmentation with A Ret-HC (Hydroquinone/Tretinoin/Hydrocortisone Acetate) cream may trigger some side effects. Tell your physician if this happens. Some examples include:

  • Redness
  • Irritated skin
  • Burning feeling
  • Dryness on the skin
  • Slight stinging sensation

If you suffer from contact dermatitis, severe irritation or any other serious adverse events not referenced here, make sure that you consult your physician immediately.


A Ret-HC (Hydroquinone/Tretinoin/Hydrocortisone Acetate) cream is for external use only. It must not be taken by mouth nor should it be allowed to come into contact with the mucus membranes.

Do not allow the skin to be exposed to UV light during treatment, as doing so will cause the bleached areas of skin to become darkened.

This cream should not be used by women who are pregnant or breastfeeding.

See Warnings and Precautions >